2018 Wylie Scholar

Dr. John Byrne received the 2018 Wylie Scholar Award for his work on “Characterization of Macrophage Biology in the Pathogenesis of Abdominal Aortic Aneurysms.” His research studied the inflammatory process of abdominal aortic aneurysm (AAA) development, which could improve the prediction and treatment of aortic aneurysms at high risk of a fatal rupture.

AAA is a swelling in the largest artery of the body, the aorta, most commonly occurring in the abdomen. As the aneurysm swells, there is a risk of rupture that can lead to rapid and fatal internal bleeding. There are currently no medications to prevent or slow down the growth of an aneurysm. Studies show that a type of white blood cell called a macrophage is present in excess in aneurysms. It is thought that macrophages contribute to the enlargement of AAA by weakening the walls of the aorta. Dr. Byrne’s work focused on understanding how macrophages cause aortic aneurysm swelling. 

Dr. Byrne completed his medical degree and a doctorate of medicine by research at The Royal College of Surgeons in Ireland. He has received awards in physiology and physics and is a recipient of the prestigious president’s medal from The Royal College of Surgeons in Ireland. He attended a fellowship at the University of Toronto after finishing the Irish Higher Surgical Training Scheme in general/vascular surgery.

“Future progress in the medical treatment of small aortic aneurysms will not take place until we, as physicians and scientists, improve our understanding of aortic biology. I am honored as a Wylie Scholar to be able to contribute to this lofty but realistic goal, which will improve the outlook for patients with this disease. Looking back at the giants of vascular surgery that make up the previous winners of this award, I am humbled and excited to be funded by Vascular Cures.”