Dr. Sarkar is investigating the genetic mechanisms regulating the growth of new arteries and ways to prevent damage from blood clots in the veins.
Deep vein thrombosis (DVT), affects more than 2 million Americans and contributes to 200,000 deaths each year by causing blood clots to form in the pelvis and legs. These clots can break off from the vein and travel to the lungs; a potentially fatal complication known as pulmonary embolism. The clots also can cause leg swelling, pain, and skin ulceration years later in a condition known as post-thrombotic syndrome. Dr. Sarkar’s research focused on post-thrombotic syndrome and the potentially important molecular role that key proteins (matrix metalloproteinases) play in vein healing following the forming of a blood clot.
Since receiving the Wylie Scholar Award, Dr. Sarkar has been promoted to Chief of Vascular Surgery at the University of Maryland. He also leads a research laboratory at their Center for Vascular and Inflammatory Diseases.