Blocked arteries can happen throughout the body and may require surgical interventions, such as creating bypass vein grafts and performing angioplasties to restore blood flow. However, up to half of angioplasties fail within one to two years, and vein grafts fail at a rate of 30-50% over five years.
A world-renowned vascular surgeon-scientist, Dr. Dardik is investigating the molecular changes that occur when a vein graft fails and developing new treatments to prevent the need for repeat surgeries. He has been able to significantly increase the success rate of vein grafts in animals and is working to translate this into treatments for patients.
Since receiving the Wylie Scholar award, Dr. Dardik has built an NIH-funded vascular laboratory at Yale University which includes surgery residents from multiple institutions and postdoctoral fellows from Japan, China, and India. He also is the Director of the Non-Invasive Vascular Laboratory at the VA Connecticut Healthcare System and lectures world wide about vascular research.