2021 Wylie Scholar

Kevin W. Southerland, MD
Assistant Professor of Surgery
Division of Vascular & Endovascular Surgery
Duke University

Dr. Kevin Southerland received the 2021 Wylie Scholar Award for his project  “Transcriptional Dynamics and Heterogeneity of Macrophages in Chronic Limb Threatening Ischemia”.

Chronic limb-threatening ischemia (CLTI) is the most severe manifestation of peripheral arterial disease.  Patients with CLTI are at high risk for limb loss and death.  A significant number of CLTI patients suffer limb loss despite successful restoration of arterial flow. Novel approaches to treat CLTI remain an unmet clinical need.  The goal of Dr. Southerland’s lab is to understand the communication signals between the various cell types in the ischemic limb.  He is particularly interested in how macrophages (a type of immune cell) interact with muscle stem cells. He believes that understanding these mechanisms will be the groundwork for the development of new therapies for CLTI patients.