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CPCR (Collaborative Patient-Centered Research) Grants 2021

The Vascular Cures CPCR Grants Program is designed to fill a critical funding gap by rewarding high-risk, collaborative science that prioritizes the patient perspective. Two 2021 CPCR grants have been awarded to two teams of established clinician-scientists at five leading academic medical centers. The grants fund 1-2-year projects that address the unmet needs related to patient-centered technology for harnessing & using data remotely in PAD and/or CLTI.   

Field Mapping Patient-Designated, Task-Specific Goals to Tracked Walking Activity 

Investigators: 
Matthew Correire MD, University of Michigan 
Oliver Aalami MD, Stanford University 
Diane Treat-Jacobson PhD RN, University of Minnesota 


Patients with PAD often seek treatment overcome leg pain that prevents them from performing a specific activity of daily life (like shopping, gardening, or going for a walk).  Because healthcare providers usually categorize symptoms based on how long, how far, or how fast a patient can walk, it can be difficult to know whether treatment is likely to help the patient achieve their activity goal or improve their quality of life.  

The project will first survey patients with PAD to identify common activities that provoke their symptoms and are often used to define their treatment goals.  This information will help establish patient-defined outcomes based on objectives they consider important.  Survey results will also be used to understand how other medical problems (like diabetes, arthritis, and heart disease) combine with PAD to affect walking. Understanding how PAD affects walking in combination with other conditions has potential to improve treatment selection by identifying those patients who are most likely to benefit.  A smartphone app will then be used to characterize walking in terms of distance, steps, duration, and rest breaks during the most common activities named by patients.  By collecting this information when and where it matters to the patient most, the results will link how healthcare providers measure PAD symptoms in clinic with how patients experience symptoms in their community.   

Results will address the gap between patient and healthcare provider perspectives on PAD symptoms, support more holistic treatment selection, and potentially develop new patient-reported outcomes based on activity-specific goals.   


Validating the Peripheral Artery Questionnaire and Vascular Quality of Life Questionnaire in a Population of Patients with Chronic Limb Threatening Ischemia

Investigators:
Jennifer Rymer MD, Duke University 
Manesh Patel MD, Duke University 
Schuyler Jones MD, Duke University 
E. Hope Weissler MD, Duke University 
Jade Hiramoto MD, UCSF 

Currently there are no health status instruments (standardized, validated questionnaires completed by patients to measure their perception of their functional well-being and health status) that have been validated or tested for use in patients with chronic limb threatening ischemia (CLTI). The research group is interested in examining several commonly used instruments that are currently used in patients with peripheral artery disease to determine how well they perform in patients with a severe form of PAD, CLTI. The  goal is to develop an increased understanding of how well these instruments perform in this subpopulation of patients, and which of them may be most useful to use in both research and clinical settings in the care and treatment of patients with CLTI.  

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