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Study maps landmarks of PAD recovery

If you’re being treated for Peripheral Artery Disease, how do you know that the treatment is actually working? Hopefully, you’ll have less pain while walking, but for what other signs should your doctor be looking? Researchers at the University of Illinois at Urbana-Champagne are hoping to answer these questions by identifying key landmarks in PAD recovery.

The researchers used multiple imaging methods to create a holistic picture of the changes in muscle tissue, blood vessels and gene expression after mice had the arteries in their legs surgically narrowed to mimic the narrowing found in PAD patients. Postdoctoral researcher Jamila Hedhli explains:

Jamila Hedhli
PhD Bioengineering, UIUC | Postdoctoral Fellow | Beckman-Brown Postdoctoral Fellowship

“The main goal of this paper is to utilize these landmarks to standardize our practice as researchers. How can we see if the benefit of certain therapies is really comparable if we are not measuring the same thing? Each imaging method gives us a different aspect of the recovery of PAD that the other tools will not. So instead of looking at only one thing, now we’re looking at a whole spectrum of the recovery. By looking at these landmarks, we’re allowing scientists to use them as a tool to say ‘At this point, I should see this happening, and if we add this kind of therapy, there should be an enhancement in recovery.’”

To read more about the team’s research, please visit the University of Illinois’ press release.

Photo from https://www.chan-lab.com/jamila-hedhli. The paper “Imaging the landmarks of vascular recovery” is available online. DOI: 10.7150/thno.36022


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