Cutting-Edge Research: Tissue-Engineered Grafts

Paul DiMuzio, MDTissue-engineered grafts, composed of adult stem cells, could one day replace synthetic vascular bypass grafts

Wylie Scholar Paul DiMuzio, MD, was author on a paper presented at the American Heart Association's Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2010 that discussed the potential use of adult stem cells and advanced tissue-engineering technology to create new blood vessels for bypass grafts. Bypass graft surgery involves using a vein graft from another part of the body to create a detour around a blocked artery, and remains a major tool to help patients with peripheral artery disease (PAD) and coronary artery disease (CAD), as well as health issues such as kidney disease that require hemodialysis access. Up to 40% of patients do not have enough of their own natural tissues, requiring surgeons to use a synthetic graft, which fails within 1-3 years at a higher rate than if their own tissues were used. Dr. DiMuzio has successfully created grafts in larger animals and is working to make this innovative treatment option available to people.

Read the American Heart Association press release.



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