The 2013 Wylie Scholar grant was awarded to support Dr. Thomas Monahan's research identifying the mechanisms responsible for vein graft, angioplasty, and stent failure. Dr. Monahan studies the body's reaction to surgery known as intimal hyperplasia, or the reduction of vessel diameter that ultimately limits the long term success of all cardiovascular reconstructions. Dr. Monahan has identified a protein, MARCKS, that when knocked down, inhibits smooth muscle cell migration and proliferation. This protein is potentially a powerful target for the prevention of this common complication.
"Support from the Wylie Scholarship has allowed me the freedom to pursue MARCKS as a potential target for therapy to prevent intimal hyperplasia. This support is especially valuable in the very competitive present funding environment. This funding will allow me to generate data and transition to an independently funded surgeon-scientist," explains Dr. Monahan. Learn more about Dr. Monahan's work here.