Paul M. Ridker, MD is the Eugene Braunwald Professor of Medicine at The Harvard Medical School and directs the Center for Cardiovascular Disease Prevention, a translational research unit at the Brigham and Women’s Hospital in Boston. He also serves on the Board of External Experts for the National Heart Lung and Blood Institute. Dr. Ridker’s research focuses on inflammatory biomarkers and novel strategies for cardiovascular disease detection and prevention.
Dr. Ridker is best known for his work developing the inflammatory hypothesis of heart disease, the clinical application of C-reactive protein (hsCRP) testing to better evaluate cardiovascular risk, and the demonstration in the JUPITER trial that statin therapy is highly effective at reducing heart attack and stroke. He is the author of over 450 original reports, 170 reviews and book chapters, and 5 textbooks related to cardiovascular medicine. Dr. Ridker is a co-inventor on a series of patents filed by the Brigham and Women’s Hospital and Harvard Medical School that relate to the use of inflammatory biomarkers in cardiovascular disease.
Charles N. Serhan, PhD is Director of the Center for Experimental Therapeutics and Reperfusion Injury (CET&RI) at Brigham and Women’s Hospital, and a Professor of Anesthesia at Harvard Medical School, affiliated with the Department of Biological Chemistry and Molecular Pharmacology. Dr. Serhan is working on cellular and molecular mechanisms that are involved in the control of local inflammatory processes.
Since inflammation plays a role in many organs and diseases, understanding this control is key to unlocking potential new treatments for diseases where chronic inflammation is thought to play a critical role. These include cardiovascular diseases, auto-immune diseases, arthritis and Alzheimer’s disease. The molecules that Dr. Serhan and colleagues are working on can serve as bio-templates for creating designer therapies to stimulate resolution of inflammation and disease.